Protein- and Peptide-Modified Synthetic Polymeric Biomaterials

This review presents all overview oil bio-hybrid approaches of integrating the structural and functional features of proteins and peptides with synthetic polymers and the resulting unique properties in such hybrids, with a focus oil bioresponsive/bioactive systems with biomaterials applications. The review is divided in two broad sections. First, we describe several examples of bio-hybrids produced by combining versatile synthetic polymers with proteins/enzymes and drugs that have resulted in (1) hybrid materials based oil responsive polymers, (2) responsive hydrogels based oil enzyme-catalyzed reactions, protein-protein interactions and protein-drug sensing, and (3) dynamic hydrogels based oil conformational changes of a protein. Next, we present hybrids produced by combining synthetic polymers with peptides, classified based oil the properties of the peptide domain: (1) peptides with different conformations, such as alpha-helical coiled-coil, and beta-sheet; (2) peptides derived from structural protein domains such as silk, elastin, titin, and collagen; and (3) peptides with other biofunctional properties such as cell-binding domains and enzyme-recognized degradation domains. (C) 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 32-48, 2010.