Journal
BIOPOLYMERS
Volume 93, Issue 3, Pages 218-228Publisher
WILEY
DOI: 10.1002/bip.21302
Keywords
alpha-synuclein; aggregate; amyloid; chaperone; heat shock protein
Categories
Ask authors/readers for more resources
Because over expression of Hsp70 molecular chaperones suppresses the toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, and various polyQ-diseases (Huntington's disease and ataxias), Hsp70 is garnering attention as a possible therapeutic agent for these various diseases. Here, I review progress in this fascinating field of molecular chaperones and neurodegeneration and describe our current understanding of the mechanisms by which Hsp70 protects cells from the PD-relared protein called alpha-synuclein (alpha-syn). (C) 2009 Wiley Periodicals, Inc. Biopolymers 93: 218-228, 2010.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available