Journal
CANCER SCIENCE
Volume 109, Issue 1, Pages 94-102Publisher
WILEY
DOI: 10.1111/cas.13425
Keywords
colorectal cancer; drug resistance; proliferation; reactive oxygen species; ursolic acid
Categories
Funding
- National Natural Sciences Foundation of China [81371683/H1819]
- Clinical Medicine Project of Jiangsu Province [BL2014023]
Ask authors/readers for more resources
It has been reported that ursolic acid has anti-tumor activity and it enhances the therapeutic effect of oxaliplatin in colorectal cancer (CRC). However, the underlying mechanisms remain unknown. In the present study, the mechanisms of the enhancement of therapeutic effects through use of ursolic acid were investigated. We treated CRC cell lines HCT8 and SW480 with ursolic acid and oxaliplatin and monitored the effects on cell proliferation, apoptosis, reactive oxygen species (ROS) production and drug resistance gene production. We discovered that treatment with a combination of ursolic acid and oxaliplatin resulted in significant inhibition of cell proliferation, significantly increased apoptosis and ROS production, and significant inhibition of drug resistance gene expression. Our study provided evidence that ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by ROS-mediated inhibition of drug resistance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available