4.6 Article

Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter

Journal

RSC ADVANCES
Volume 8, Issue 59, Pages 34000-34003

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ra04325f

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Funding

  1. National Science Foundation of China [21502118]

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A practical sulfa-Michael/aldol cascade reaction of 1,4-dithiane-2,5-diol and alpha-aryl-beta-nitroacrylates has been developed, which allows efficient access to functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter in moderate to good yields with high enantioselectivities.

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