Journal
BIOPOLYMERS
Volume 91, Issue 7, Pages 505-513Publisher
WILEY
DOI: 10.1002/bip.21164
Keywords
docking; peptides; peptidomimetics; protein motifs; computer-aided drug design
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Funding
- United States-Israel Binational Science Foundation [2007296]
- Niedersachsen-Israeli Research
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With the decline in productivity of drug-development efforts, novel approaches to rational drug design are being introduced and developed. Naturally occurring and synthetic peptides are emerging as novel promising compounds that can specifically and efficiently modulate signaling pathways in vitro and in vivo. We describe sequence-based approaches that use peptides to mimic proteins in order to inhibit the interaction of the mimicked protein with its partners. We then discuss a structure-based approach, in which protein-peptide complex structures are used to rationally design and optimize peptidic inhibitors. We survey flexible peptide docking techniques and discuss current challenges and future directions in the rational design of peptidic inhibitors. (C) 2009 Wiley Periodicals, Inc. Biopolymers 91:505-513,2009.
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