4.7 Article

A ratiometric fluorescent probe for bioimaging and biosensing of HBrO in mitochondria upon oxidative stress

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 86, Pages 12198-12201

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc07125j

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Funding

  1. NSFC [21635003, 21325521]
  2. Program of Shanghai Subject Chief Scientist [15XD1501600]

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A novel ratiometric fluorescent probe with high selectivity and sensitivity was designed and developed for bioimaging and biosensing of HBrO in mitochondria. Using this useful tool with low cytotoxicity and good biocompatibility, it was found that O-2(center dot-)-induced oxidative stress triggered the burst of HBrO in mitochondria.

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