Hemiaminal ether linkages provide a selective release of payloads from polymer conjugates

We introduce here hemiaminal ether linkages, synthesized by coupling a vinyl ether and a 1,2,3-triazole, as responsive groups in polymers to allow the selective release of a functional molecule. The release kinetics of benzotriazole from polymer nanoparticles shows a fast release at low pH values and a prolonged or even no release under mildly acidic conditions and at neutral pH.