Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 97, Pages 13742-13745Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc05691a
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Ceramide plays key roles in autophagy, inflammation and apoptosis. However, little is known about the molecular mechanisms regulating its function and only a handful of cellular effectors are known for this lipid. Here we show that azide-tagged sphingolipids are powerful tools to identify ceramide targets. The combination of a protein array analysis and a mass spectrometry-based proteomic profiling successfully detects known ceramide-binding proteins and identifies others not yet reported, several of which we validated using a variety of techniques.
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