Journal
NANOSCALE
Volume 10, Issue 44, Pages 20717-20722Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr06186f
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Funding
- National Research Foundation (NRF) - Ministry of Science, ICT & Future Planning [NRF-2017H1D3A1A01014182, NRF-2017M2A2A6A04093177]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) [HI16C1118]
- Ministry of Health & Welfare, Republic of Korea
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The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.
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