Journal
BIOPHYSICAL JOURNAL
Volume 104, Issue 3, Pages L1-L3Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2012.11.3838
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Funding
- National Institutes of Health
- Harvard College Research Program
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To understand the variation of protein sequences in nature, we need to reckon with evolutionary constraints that are biophysical, cellular, and ecological. Here, we show that under the global selection against protein misfolding, there exists a scaling among protein folding stability, protein cellular abundance, and effective population size. The specific scaling implies that the several-orders-of-magnitude range of protein abundances in the cell should leave imprints on extant protein structures, a prediction that is supported by our structural analysis of the yeast proteome.
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