Journal
BIOPHYSICAL JOURNAL
Volume 105, Issue 9, Pages L19-L22Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2013.09.023
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Funding
- National Science Foundation CAREER [MCB-0845099]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0845099] Funding Source: National Science Foundation
- Division Of Physics
- Direct For Mathematical & Physical Scien [1308264] Funding Source: National Science Foundation
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The ability of biomolecules to fold and to bind to other molecules is fundamental to virtually every living process. Advanced experimental techniques can now reveal how single biomolecules fold or bind against mechanical force, with the force serving as both the regulator and the probe of folding and binding transitions. Here, we present analytical expressions suitable for fitting the major experimental outputs from such experiments to enable their analysis and interpretation. The fit yields the key determinants of the folding and binding processes: the intrinsic on-rate and the location and height of the activation barrier.
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