4.7 Article

Controlled synthesis of Fe3O4@ZIF-8 nanoparticles for drug delivery

Journal

CRYSTENGCOMM
Volume 20, Issue 46, Pages 7486-7491

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ce01302k

Keywords

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Funding

  1. National Natural Science Foundation of China [21675091, 21574072, 21874078]
  2. Taishan Young Scholar Program of Shandong Province [tsqn20161027]
  3. Major Science and Technology Innovation Project of Shandong Province [2018CXGC1407]
  4. Key Research and Development Project of Shandong Province [2016GGX102028, 2016GGX102039, 2017GGX20111]
  5. Natural Science Foundation of Shandong Province [ZR2017BB003]
  6. Postdoctoral Scientific Foundation of China [2017M622126]
  7. Project of Shandong Province Higher Educational Science and Technology Program [J15LC20]
  8. People's Livelihood Science and Technology Project of Qingdao [173378nsh, 166257nsh]
  9. Innovation Leader Project of Qingdao [168325zhc]
  10. Postdoctoral Scientific Research Foundation of Qingdao
  11. First Class Discipline Project of Shandong Province

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Encapsulating well-defined nanoparticles (NPs) into ZIF-8 to form core-shell structures not only can minimize the drawbacks and maximize the advantages of the disparate components but also may provide synergistic functionality. This work presents novel one-pot synthetic methods to produce Fe3O4@ZIF-8 NPs. Moreover, the morphology of Fe3O4@ZIF-8 NPs can be easily controlled by changing the synthesis conditions (time, temperature, and dosage). The as-obtained Fe3O4@ZIF-8 NPs have good dispersibility and a large specific surface area and they are proven to have potential applications as drug delivery models with good biocompatibility, high drug loading and good pH responsiveness.

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