Journal
BIOMOLECULES
Volume 9, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/biom9010022
Keywords
cell-penetrating peptides; membrane translocation; delivery systems; therapeutic molecule; nanoparticles
Categories
Funding
- FEDER-Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020-Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020
- Portuguese funds through FCT-Fundacao para a Ciencia e a Tecnologia [POCI-01-0145-FEDER-007274]
- iMed. ULisboa [UID/DTP/04138/2013]
- FCT
- FEDER (European Union) [IF/00092/2014/CP1255/CT0004]
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Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid residues capable of penetrating biological barriers and cellular membranes. Furthermore, CPP have become an alternative strategy to overcome some of the current drug limitations and combat resistant strains since CPPs are capable of delivering different therapeutic molecules against a wide range of diseases. In this review, we address the recent conjugation of CPPs with nanoparticles, which constitutes a new class of delivery vectors with high pharmaceutical potential in a variety of diseases.
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