Journal
POLYMER CHEMISTRY
Volume 10, Issue 23, Pages 2986-2990Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8py01719k
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Funding
- ERC [638661, 789182]
- Leverhulme Trust RPG [2015 0194]
- BBSRC [BB/R506588/1]
- University of Warwick
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Antifreeze proteins (AFPs) have many potential applications, ranging from cryobiology to aerospace, if they can be incorporated into materials. Here, a range of engineered AFP mutants were prepared and site-specifically conjugated onto RAFT polymer-stabilized gold nanoparticles to generate new hybrid multivalent ice growth inhibitors. Only the SNAP-tagged AFPs lead to potent 'antifreeze' active nanomaterials with His-Tag capture resulting in no activity, showing the mode of conjugation is essential. This versatile strategy will enable the development of multivalent AFPs for translational and fundamental studies.
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