Journal
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
Volume 17, Issue -, Pages 465-469Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bcab.2018.12.026
Keywords
Diabetes Mellitus; Fermentation; Kombucha; Pancreatic beta-cells; Fasting plasma glucose
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Funding
- Ministry of Research, Technology and Higher Education, Republic of Indonesia [063/SP2H/LT/DRPM/IV/2017]
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The research compared antidiabetic activity of snake fruit Kombucha, black tea Kombucha and metformin in streptozotocin-induced diabetic rats. Snake fruit Kombucha, black tea Kombucha and metformin were orally administered to the diabetic rats daily during a 28-day experiment. Fasting plasma glucose (FPG) levels, superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels and lipid profiles (total triglyceride, total cholesterol, LDL-cholesterol and HDL-cholesterol) of the blood plasma were investigated. Pancreas immunohistochemical study and beta-cells quantification were also conducted. The products significantly (p < 0.05) reduced fasting plasma glucose levels (67-76%) and improved oxidative stress indices and lipid profiles. From immunohistochemical staining of pancreatic tissues, pancreatic beta-cells were also improved in the diabetic rats by the products. The snake fruit Kombucha compared with the metformin but better than the black tea Kombucha as a diabetes therapy agent.
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