Journal
BIOPHYSICAL JOURNAL
Volume 101, Issue 4, Pages 875-884Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2011.06.058
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Funding
- United Kingdom Engineering and Physical Sciences Research Council [EP/H004319/1]
- Human Frontiers Science Program [RGP0049/2010-C102]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
- EPSRC [EP/H010106/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H010106/1] Funding Source: researchfish
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Homologous pairing and braiding (supercoiling) have crucial effects on genome organization, maintenance, and evolution. Generally, the pairing and braiding processes are discussed in different contexts, independently of each other. However, analysis of electrostatic interactions between DNA double helices suggests that in some situations these processes may be related. Here we present a theory of DNA braiding that accounts for the elastic energy of DNA double helices as well as for the chiral nature of the discrete helical patterns of DNA charges. This theory shows that DNA braiding may be affected, stabilized, or even driven by chiral electrostatic interactions. For example, electrostatically driven braiding may explain the surprising recent observation of stable pairing of homologous double-stranded DNA in solutions containing only monovalent salt. Electrostatic stabilization of left-handed braids may stand behind the chiral selectivity of type II topoisomerases and positive plasmid supercoiling in hyperthermophilic bacteria and archea.
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