Journal
BIOPHYSICAL JOURNAL
Volume 101, Issue 4, Pages 970-975Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2011.06.060
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Funding
- LLNL
- U.S. Department of Energy through the LLNL [DE-AC52-07NA27344]
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Apolipoprotein A-I plays a central role in the solution structure of high-density lipoproteins. Determining the stoichiometry of lipid-bound apo A-I in the hydrated state is therefore fundamental to understanding how high-density lipoproteins form and function. Here, we use the quantum optical phenomenon of photon antibunching to determine the number of apo A-I molecules bound to discoidal lipoproteins and compare this with values obtained by photon-counting histogram analysis. Both the photon antibunching and photon-counting analyses show that reconstituted high-density lipoprotein particles contain two apo A-I molecules, which is in agreement with the commonly accepted double-belt model.
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