Journal
MATERIALS HORIZONS
Volume 6, Issue 1, Pages 169-175Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8mh00908b
Keywords
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Funding
- National Natural Science Foundation of China [31771036, 51573096, 51703132]
- Basic Research Program of Shenzhen [JCYJ20170412111100742, JCYJ20160422091238319]
- Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project [2018B030308003]
- Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China [161032]
- China Postdoctoral Science Foundation [2018M633138]
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Developing a simple and degradable synergistic therapy nanosystem based on glucose oxidase (GOx) remains a challenge. Inspired by the chain reactions among silver nanoparticles, GOx and intratumoral glucose, a degradable GOx-conjugated silver nanocube (AgNC-GOx) for synergistic cancer starving-like/metal ion therapy is presented. The combination of glucose depletion, toxic H2O2 and Ag ions effectively inhibits tumor growth with minimal adverse effects.
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