Journal
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
Volume 4, Issue 5, Pages 508-512Publisher
WILEY
DOI: 10.1002/lio2.300
Keywords
Human papilloma virus; HPV-associated oropharyngeal squamous cell carcinoma; adaptive immunity; innate immunity
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Funding
- NIH [CA227838]
- National Cancer Institute Cancer Center [P30CA168524]
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Human papilloma virus (HPV) has been implicated in the development of oropharyngeal squamous cell carcinoma (OPSCC) and is directly attributed to its increasing incidence. The immune microenvironment surrounding HPV-associated OPSCC tumors is complex and plays a critical role in the carcinogenic process. The neoplastic mechanism includes cells of the innate immunity such as macrophages, and dendritic cells as well as cells of the adaptive immune process such as CD8+ T-cells. The intricate interactions between these two arms of the immune system allow for a pro-inflammatory and pro-tumorigenic environment. Intensive efforts are underway to gain a greater understanding of the mechanisms involved in the immune system's role in tumor development. This study seeks to summarize the current knowledge pertaining to role of the innate and adaptive immune response in HPV-associated OPSCC. Level of Evidence 3a
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