Journal
FOOD AND AGRICULTURAL IMMUNOLOGY
Volume 30, Issue 1, Pages 979-994Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09540105.2019.1652250
Keywords
Immunological liver injury; inflammatory factor; antioxidant effects; Salvia miltiorrhiza polysaccharides (SMPs)
Funding
- National Natural Science Foundation of China [31872506]
- Graduate Education - Graduate Innovation Program of Hebei Province, China [1009080]
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The current study was conducted to investigate the hepatoprotective effects of Salvia miltiorrhiza polysaccharides (SMP) against lipopolysaccharide (LPS) induced liver injury. The mice were treated with SMP first and LPS later. Results showed that SMPs significantly reduced the activities of serum alanine aminotransferase (ALT), aspartate transaminase (AST), total bilirubin (TBIL), malondialdehyde (MDA) and contents of inflammation factors and mRNA expressions in LPS induced liver injury mice. However, SMP significantly increased the contents of glutathione (GSH), Superoxide dismutase (SOD) and Total antioxidant capacity (T-AOC). SMP also downregulated the expressions of p-p65, p-I kappa B alpha, inducible nitricoxide synthase (iNOS) and improved the expression of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and Heme Oxygenase-1 (HO-1). The study indicates SMP protects the liver via attenuating inflammatory reactions and antioxidant effects.
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