Journal
CCS CHEMISTRY
Volume 1, Issue 1, Pages 138-147Publisher
CHINESE CHEMICAL SOC
DOI: 10.31635/ccschem.019.20180012
Keywords
protein hydrogel; protein folding; actuation; force spectroscopy; single molecule
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Canada Foundation for Innovation
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Mechanochemical coupling cycles underlie the work- generation mechanisms of biological systems and are realized by highly regulated conformational changes of the protein machineries. However, it has been challenging to utilize protein conformational changes to do mechanical work at the macroscopic level in biomaterials, and it remains elusive to construct macroscopic mechanochemical devices based on molecular-level mechanochemical coupling systems. Here, the authors demonstrate that protein folding can be utilized to realize protein's mechanochemical cycles at both single-molecule and macroscopic levels. Our results demonstrate, for the first time, the successful harnessing of mechanical work generated by protein folding in a macroscopic protein hydrogel device, and the work generated by protein folding compares favorably with the energy output of molecular motors. Our work bridges a gap between single-molecule and macroscopic levels, and paves the way to utilizing proteins as building to design protein-based artificial muscles and soft actuators. [GRAPHICS] .
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