Journal
BIOPHYSICAL JOURNAL
Volume 98, Issue 6, Pages L15-L17Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2009.11.029
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Funding
- National Institutes of Health [GM058187]
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In receptor-ligand binding, a question that generated considerable interest is whether the mechanism is induced fit or conformational selection. This question is addressed here by a solvable model, in which a receptor undergoes transitions between active and inactive forms. The inactive form is favored while unbound but the active form is favored while a ligand is loosely bound. As the active-inactive transition rates increase, the binding mechanism gradually shifts from conformational selection to induced fit. The timescale of conformational transitions thus plays a crucial role in controlling binding mechanisms.
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