Journal
BIOPHYSICAL JOURNAL
Volume 99, Issue 3, Pages 716-725Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2010.05.016
Keywords
-
Categories
Funding
- Korean government Ministry of Education, Science and Technology (MEST) [2009-0086964, 2010-0017662]
- Engineering and Physical Science Research Council [GR/572023/01]
- British Council
- Royal Society
- National Research Foundation of Korea [2009-0086964, 2010-0017662] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Experimental data (e.g., genetic lineage and cell population studies) on intestinal crypts reveal that regulatory features of crypt behavior, such as control via morphogen gradients, are remarkably well conserved among numerous organisms (e.g., from mouse and rat to human) and throughout the different regions of the small and large intestines. In this article, we construct a partial differential equation model of a single colonic crypt that describes the spatial distribution of Wnt pathway proteins along the crypt axis. The novelty of our continuum model is that it is based upon assumptions that can be directly related to processes at the cellular and subcellular scales. We use the model to predict how the distributions of Wnt pathway proteins are affected by mutations. The model is then extended to investigate how mutant cell populations can invade neighboring crypts. The model simulations suggest that cell crowding caused by increased proliferation and decreased cell loss may be sufficient for a mutant cell population to colonize a neighboring healthy crypt.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available