Journal
BIOMATERIALS RESEARCH
Volume 23, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1186/s40824-019-0176-8
Keywords
Electrical stimulation; Tissue engineered materials; Regenerative medicine
Funding
- Natural Science Foundation of Zhejiang Province [LY20E010006, LQ16E020006]
- National Natural Science Foundation of China [51502265]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Republic of Korea [2015R1D1A1A09058875]
- Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences
- Project of Administration of Traditional Chinese Medicine of Zhejiang Province of China [2018ZB011]
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Recently, electrical stimulation as a physical stimulus draws lots of attention. It shows great potential in disease treatment, wound healing, and mechanism study because of significant experimental performance. Electrical stimulation can activate many intracellular signaling pathways, and influence intracellular microenvironment, as a result, affect cell migration, cell proliferation, and cell differentiation. Electrical stimulation is using in tissue engineering as a novel type of tool in regeneration medicine. Besides, with the advantages of biocompatible conductive materials coming into view, the combination of electrical stimulation with suitable tissue engineered scaffolds can well combine the benefits of both and is ideal for the field of regenerative medicine. In this review, we summarize the various materials and latest technologies to deliver electrical stimulation. The influences of electrical stimulation on cell alignment, migration and its underlying mechanisms are discussed. Then the effect of electrical stimulation on cell proliferation and differentiation are also discussed.
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