Journal
BIOMATERIALS RESEARCH
Volume 23, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1186/s40824-019-0164-z
Keywords
Hyaluronate; Poly(Lactide-co-Glycolide); Alopecia; Minoxidil; Transdermal drug delivery
Funding
- National Research Foundation of Korea [2018R1C1B5035631, 2019R1F1A1062216, 2019R1A4A1024116]
- Pusan National University Research Grant
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BackgroundAlopecia has become a very common disease that many people around the world are suffered. Minoxidil (MXD) is the most well-known commercialized drug in its treatment. However, in the case of MXD administration, there are some problems with low efficiency of transdermal delivery and additional side effects.MethodMXD and Rhodamine B (Rho B) are encapsulated in poly(Lactide-co-Glycolide) grafted hyaluronate nanoparticles (HA-PLGA/MXD NPs, HA-PLGA/Rho B NPs) which is prepared with W/O/W solvent evaporation method. After then, the investigation is carried out to confirm the feasibility of NPs in alopecia treatment.ResultsBoth of HA-PLGA/MXD NPs and HA-PLGA/Rho B NPs are successfully prepared. In addition, it is confirmed that HA-PLGA NPs sufficiently delivered to cells without any significant cytotoxicity by cell viability, cellular uptake and skin permeation test.ConclusionTaken together, HA-PLGA NPs as a transdermal delivery carrier to hair follicle cells can be exploited to develop the efficient and effective platform of transdermal drug delivery for the treatment of various diseases.
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