Journal
FOOD & FUNCTION
Volume 11, Issue 9, Pages 7415-7420Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo02017f
Keywords
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Funding
- National Key Research and Development Program of China [2019YFD0902005]
- National Natural Science Foundation of China [31972084]
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Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the world at an unprecedented rate. In the present study, 4 marine sulfated polysaccharides were screened for their inhibitory activity against SARS-CoV-2, including sea cucumber sulfated polysaccharide (SCSP), fucoidan from brown algae, iota-carrageenan from red algae, and chondroitin sulfate C from sharks (CS). Of them, SCSP, fucoidan, and carrageenan showed significant antiviral activities at concentrations of 3.90-500 mu g mL(-1). SCSP exhibited the strongest inhibitory activity with IC(50)of 9.10 mu g mL(-1). Furthermore, a test using pseudotype virus with S glycoprotein confirmed that SCSP could bind to the S glycoprotein to prevent SARS-CoV-2 host cell entry. The three antiviral polysaccharides could be employed to treat and prevent COVID-19.
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