Journal
ACTA DERMATO-VENEREOLOGICA
Volume 100, Issue -, Pages 54-64Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-3384
Keywords
psoriasis; genetics; precision medicine; disease progression; treatment outcome
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Funding
- Health Data Research UK [MR/S003126/1]
- Chief Scientist Office of the Scottish Government Health and Social Care Directorates
- Public Health Agency (Northern Ireland)
- British Heart Foundation
- Wellcome Trust
- NIHR Biomedical Research Centre at King's College London/Guy's and St Thomas' NHS Foundation Trust
- Engineering and Physical Sciences Research Council
- Economic and Social Research Council
- Department of Health and Social Care (England)
- UK Medical Research Council
- Health and Social Care Research and Development Division (Welsh Government)
- MRC [MR/T02383X/1, MR/S003126/1] Funding Source: UKRI
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Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent progress in elucidating the genetic basis of psoriasis, particularly through large genome-wide association studies. We illustrate the power of genetic analyses for disease stratification. Psoriasis can be stratified by phenotype (common plaque versus rare pustular variants), or by outcome (prognosis, comorbidities, response to treatment); recent progress has been made in delineating the genetic contribution in each of these areas. We also highlight how genetic data can directly inform the development of effective psoriasis treatments.
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