Sulfuric Acid Catalyzed Rapid Nucleophilic Substitution of Propargyl Alcohols

Sulfuric acid efficiently catalyzes the direct substitution of the hydroxyl group of propargylic alcohols with a variety of C- and O-based nucleophiles to aid C-C and C-O bond formation. The reactions can be performed in an undried solvent under air atmosphere to obtain the desired products in good yields. In most cases, the reaction proceeds to completion in 1 min at room temperature.