Journal
JOURNAL OF CHEMICAL INFORMATION AND MODELING
Volume 55, Issue 3, Pages 564-571Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ci5006417
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- Research Board of the Ghent University (BOF)
- Research Foundation Flanders (FWO)
- Vrije Universiteit Brussel (VUB)
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Atomic charges are a key concept to give more insight into the electronic structure and chemical reactivity. The Hirshfeld-I partitioning scheme applied to the model protein human 2-cysteine peroxiredoxin thioredoxin peroxidase B is used to investigate how large a protein fragment needs to be in order to achieve convergence of the atomic charge of both neutral and negatively charged residues. Convergence in atomic charges is rapidly reached for neutral residues, but not for negatively charged ones. This study pinpoints difficulties on the road toward accurate modeling of negatively charged residues of large biomolecular systems in a multiscale approach.
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