Journal
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
Volume 13, Issue -, Pages 4341-4351Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DMSO.S283413
Keywords
asprosin; type 2 diabetes mellitus; diabetic nephropathy
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Funding
- National Natural Science Foundation of China [81870548, 81570721]
- Social Development Project of Jiangsu Province [BE2018692]
- Natural Science Foundation of Jiangsu Province, China [BK20191222]
- High Caliber Medical Personnel Foundation of Jiangsu Province [LGY2016053]
- Six Talent Peaks Project in Jiangsu Province [2015-WSN-006]
- Fifth 169 project Scientific Research Project of Zhenjiang City, Jiangsu Province
- Scientific Research Projects of Jiangsu Health and Family Planning Commission [Y2018109]
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Aim: We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria in patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed. Methods: Based on urinary albumin/creatinine ratio (UACR), 207 T2DM patients were divided into T2DM patients with normoalbuminuria (UACR<30 mg/g), microalbuminuria (30 <= UACR<300 mg/g), and macroalbuminuria (UACR >= 300 mg/g). Serum asprosin levels were determined by enzyme-linked immunosorbent assay. Results: Comparatively, the serum asprosin levels in T2DM patient groups with macro-albuminuria [2.37 (1.63-3.57)] and microalbuminuria [2.10 (1.60-2.90)] were significantly increased than the normoalbuminuria group [1.59 (1.18-2.09)] (P<0.001). Importantly, the serum level of asprosin was positively correlated with UACR (r=0.304, P<0.001), creatinine (r=0.157, P=0.024), blood urea nitrogen (BUN) (r=0.244, P<0.001), and negatively with glomerular filtration rate (eGFR) (r=-0.159, P=0.022). Furthermore, multiple stepwise regression analyses showed that asprosin was significantly and independently related to UACR, BUN, DBP, and LDL-C (P<0.05). Besides, after adjustment for the confounders, the serum asprosin level was constantly and independently associated with the development of albuminuria in T2DM patients [OR (95% CI): 2.003 (1.37 similar to 2.928), P <0.001]. Conclusion: Obviously, the serum asprosin level was independently correlated with UACR in T2DM patients, which implies circulating asprosin may play an essential role in the pathogenesis of diabetic nephropathy.
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