Journal
BIOPHYSICAL JOURNAL
Volume 99, Issue 12, Pages L91-L93Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2010.08.072
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Funding
- The Netherlands Organisation for Scientific Research [700-57-303, 700-57-404]
- National Supercomputing Facilities (NCF) [SH-148]
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Line-active molecules (linactants) that bind to the boundary interface between different fluid lipid domains in membranes have a strong potential as regulators of the lateral heterogeneity that is important for many biological processes. Here, we use molecular dynamics simulations in combination with a coarse-grain model that retains near-atomic resolution to identify lipid species that can act as linactants in a model membrane that is segregated into two lipid domains of different fluidity. Our simulations predict that certain hybrid saturated/unsaturated chain lipids can bind to the interface and lower the line tension, whereas cone-shaped lysolipids have a less pronounced effect.
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