Journal
BIOPHYSICAL JOURNAL
Volume 96, Issue 11, Pages 4725-4732Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2009.03.038
Keywords
-
Categories
Funding
- Nanoinitiative Munich (NIM)
- Munich-Centre for Advanced Photonics (MAP)
- DFG [Ba2029/8-1]
- CompInt in the framework of the ENB Bayern
Ask authors/readers for more resources
Although the structure of cross-linking molecules mainly determines the structural organization of actin filaments and with that the static elastic properties of the cytoskeleton, it is largely unknown how the biochemical characteristics of transiently cross-linking proteins (actin-binding proteins (ABPs)) affect the viscoelasticity of actin networks. In this study, we show that the macroscopic network response of reconstituted actin networks can be traced back to the microscopic interaction potential of an individual actin/ABP bond. The viscoelastic response of cross-linked actin networks is set by the cross-linker off-rate, the binding energy, and the characteristic bond length of individual actin/ABP interactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available