Journal
BIOPHYSICAL JOURNAL
Volume 96, Issue 6, Pages 2344-2352Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2008.11.065
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Funding
- Defense Microelectronics Activity (DMEA) [H94003-06-2-0607, H94003-07-2-0702]
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We present a molecular system where polymerization is controlled externally by tuning the elastic energy of the monomers. The elastic energy, provided by a DNA molecular spring, destabilizes the monomer state through a process analogous to domain swapping. This energy can be large (of similar to 10 kT) and thus drive polymerization at relatively low monomer concentrations. The monomer-dimer equilibrium provides a measurement of the elastic energy of the monomer, which in this construction appears limited by kink formation in the DNA molecular spring, in accord with previous theoretical and experimental investigations of the elasticity of sharply bent DNA.
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