Journal
MATHEMATICAL BIOSCIENCES AND ENGINEERING
Volume 17, Issue 2, Pages 1757-1775Publisher
AMER INST MATHEMATICAL SCIENCES-AIMS
DOI: 10.3934/mbe.2020092
Keywords
Hepatitis B virus; transmission dynamics; Lyapunov functional; model application; sensitivity analysis
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Funding
- Natural Science Basic Research Plan in Shaanxi Province of China [2018JM1011]
- National Natural Science Foundation of China [11961071]
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The incubation period for Hepatitis B virus (HBV) within the human is epidemiologically significant because it is typically of long duration (1.5 similar to 6 months) and the disease transmission possibility may be increased due to more contact from the patients in this period. In this paper, we investigate an SEICRV epidemic model with time delay to research the transmission dynamics of Hepatitis B disease. The basic reproductive number R-0 is derived and can determine the dynamics of the model. The disease-free equilibrium is globally asymptotically stable if R-0 < 1 and unstable if R-0 > 1. As R-0 > 1, the model admits a unique endemic equilibrium which is locally asymptotically stable. The endemic equilibrium is globally asymptotically stable when the vertical transmission is ignored. Numerically, we study the Hepatitis B transmission case in Xinjiang, China. Using the Hepatitis B data from Xinjiang, the basic reproductive number is estimated as 1.47 (95% CI: 1.34-1.50). By the end of 2028, the cumulative number of Hepatitis B cases in Xinjiang will be estimated about 700,000 if there is no more effective preventive measures. The sensitivity analysis of R-0 in terms of parameters indicates prevention and treatment for chronic patients are key measures in controlling the spread of Hepatitis B in Xinjiang.
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