Journal
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
Volume 14, Issue 5, Pages 907-909Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dsx.2020.05.034
Keywords
Lactobacillus; Probiotic; Diabetes mellitus; Gut microbiota
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Background and aims: Probiotic supplementation improves glycemic control in persons with diabetes and the current study examined whether these benefits extend to healthy individuals. Methods: The current study was a 90-day placebo-controlled, double-blind, randomized clinical trial of Lactobacillus rhamnosus GG in healthy middle-aged and older adults. Fasting blood glucose and HbA1c were quantified at baseline and follow up. Results: ANCOVA controlling for baseline values showed group differences in follow up HbA1c [F (1,90) = 8.44, p = 0.005]; HbA1c values increased in the placebo group, though remained stable in the probiotic group. Conclusions: If replicated, Lactobacillus rhamnosus GG may protect against changes in glycemic control. Published by Elsevier Ltd on behalf of Diabetes India.
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