Journal
MATERIALS HORIZONS
Volume 7, Issue 10, Pages 2651-2661Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0mh01344g
Keywords
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Funding
- National Natural Science Foundation of China (NSFC) [91848201, 11772004, 11772006, 11972001, 11972002]
- Beijing Natural Science Foundation [L172002]
- Shenzhen Institute of Synthetic Biology Scientific Research Program [DWKF20190002]
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Adhesive hydrogels hold great promise in multiple biomedical applications. However, there still exist practical challenges in underwater specific adhesion of hydrogels to biotic surfaces. Inspired by ctenophores, we develop an exquisite design of adhesive hydrogel based on polyacrylic acid (PAA), chitosan, tannic acid (TA) and Al3+, where the inhibition of a high amount TA on gelation is eliminated. This kind of hydrogel has high toughness and fast self-healable capability both in air and underwater. With the aid of electrostatic interactions and dynamic catechol chemistry, it is capable of achieving high-efficiency, specific and reversible underwater adhesion to multiple biological tissues like porcine skin, muscle, liver, intestines, and shrimp or crab shells, in diverse aqueous environments. Furthermore, the hydrogel with excellent biocompatibility and antibacterial ability is also suitable for tissue repair. This ctenophore-inspired work opens new avenues for designing and fabricating high-performance hydrogels with efficient specific underwater adhesiveness to diverse biomaterials.
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