Journal
NEUROPSYCHIATRIC DISEASE AND TREATMENT
Volume 16, Issue -, Pages 2153-2159Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NDT.S269210
Keywords
inflammation; neutrophil-to-lymphocyte ratio; depression; intracerebral hemorrhage
Categories
Funding
- Anhui Province Natural Science Foundation of Department of Education [KJ2016A210]
- Huainan Key Scientific Research Project [2017A0593]
- Natural Science Foundation of Bengbu Medical College [BYKY18191]
Ask authors/readers for more resources
Purpose: Inflammation plays a critical role in the development of depression after intracerebral hemorrhage (ICH), while neutrophil-to-lymphocyte ratio (NLR) has been identified as a novel comprehensive inflammatory indicator in recent years. The aim of this study was to examine the association between NLR and depression after ICH. Patients and Methods: From January 2016 to December 2018, ICH patients were prospectively enrolled. NLR was measured at admission. Depression at 3 months after ICH was diagnosed according to the Hamilton Depression Scale (HAMD). Results: Of the 372 enrolled patients, 107 (28.8%) were diagnosed with depression at 3 months after ICH. Patients with depression had a higher NLR (6.15 vs 3.55, P < 0.001). Logistic regression analysis detected that after adjusting for major confounders, NLR remained independently associated with depression after ICH (OR = 2.25, 95% CI: 1.45-3.49, P < 0.001). Moreover, NLR acted as the optimal variable for prediction, with the optimal predictive threshold of 4.53 in ROC analysis. Conclusion: Elevated NLR is associated with depression at 3 months after ICH, suggesting that NLR may be a significant biomarker to predict depression after ICH.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available