4.1 Article

Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management

Journal

Publisher

SOC BRASILEIRA MEDICINA TROPICAL
DOI: 10.1590/0037-8682-0401-2020

Keywords

COVID-19; Aspergillus; Postmortem evidence

Funding

  1. FAPEAM through PAPAC public call
  2. FAPEAM through POSGRAD public call

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We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.

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