Journal
JOURNAL OF CHEMICAL EDUCATION
Volume 92, Issue 8, Pages 1390-1393Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ed5008603
Keywords
Upper-Division Undergraduate; Organic Chemistry; Collaborative/Cooperative Learning; Hands-On Learning/Manipulatives; Chirality/Optical Activity; Chromatography; Enantiomers; Hydrogen Bonding; Asymmetric Synthesis
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An experiment carried out by advanced undergraduate students in a project-based laboratory course is described. Taking into account the positive effects of working in teams, which has been key for successful research in industry and academia, a cooperative learning experience in the laboratory was developed. Students working in teams of four synthesize two alkaloid-derived thioureas starting from a chiral pool (quinidine and quinine). The thioureas are used to catalyze an enantioselective Michael reaction between acetylacetone and trans-4-methyl-beta-nitrostyrene, providing a platform for discussion of stereochemistry and chirality transfer events. Qualitative analysis of the reaction enantioselectivity is performed by polarimetry, which allows students to assign product optical rotations (+/-) with their absolute configurations (S/R). Students are exposed to an entire research process: analysis of primary literature, discussion with colleagues, planning laboratory schedules, and execution of experiments.
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