Journal
NATURE REVIEWS IMMUNOLOGY
Volume 20, Issue 4, Pages 217-228Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41577-019-0247-z
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Funding
- NIMH NIH HHS [R01 MH119459] Funding Source: Medline
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Studies in recent years have uncovered the crucial function of neuroimmune interactions in maintaining tissue homeostasis and protection. Immune and neuronal cells are often colocalized at defined anatomical sites, forming neuroimmune cell units, where both cell types coordinate their responses. In addition, even when located at distant sites, neuronal cells can receive signals from and provide signals to peripheral immune cells. As such, neuroimmune interactions are found across multiple organs and have recently emerged as important regulators of physiology. In this Review, we focus on the impact of bidirectional neuroimmune interactions in tissue biology, organ physiology and embryonic development. Finally, we explore how this fast-evolving field is redefining the tenets of inter-organ and intergenerational communications. Immune cells and neural cells interact in numerous tissues and organs and can have local and far-reaching physiological effects. Understanding these intimate bidirectional interactions is providing insight into the gut-brain axis, as well as the maternal gut-fetal brain axis.
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