Journal
NATURE REVIEWS IMMUNOLOGY
Volume 20, Issue 1, Pages 40-54Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41577-019-0198-4
Keywords
-
Categories
Funding
- Excellence Initiative (Competence Centres for Excellent Technologies -COMET) of the Austrian Research Promotion Agency FFG: Research Centre of Excellence in Vascular Ageing Tyrol
- VASCage (K-Project) [843536]
- BMVIT, BMWFW
- Standortagentur Tirol
- Gilead Biosciences Fellowship
- Austrian Science Fund [P 29379-B28]
- Austrian Society of Gastroenterology and Hepatology (OGGH)
- European Crohn's and Colitis Organization (ECCO)
- Abisch Frenkel Foundation for the Promotion of Life Sciences
- Gurwin Family Fund for Scientific Research
- Leona M. and Harry B. Helmsley Charitable Trust
- Crown Endowment Fund for Immunological Research
- estate of L. Hershkovich
- Benoziyo Endowment Fund for the Advancement of Science
- Adelis Foundation - European Research Council
- Marie Curie Integration grant
- German-Israeli Foundation for Scientific Research and Development
- Israel Science Foundation
- Minerva Foundation
- Rising Tide Foundation
- Helmholtz Foundation
- European Foundation for the Study of Diabetes
- Howard Hughes Medical Institute (HHMI)
Ask authors/readers for more resources
Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2 diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these disorders are characterized by alterations in the intestinal microbiota composition and its metabolites, which translocate from the gut across a disrupted intestinal barrier to affect various metabolic organs, such as the liver and adipose tissue, thereby contributing to metabolic inflammation. Here, we discuss some of the recently identified mechanisms that showcase the role of the intestinal microbiota and barrier dysfunction in metabolic inflammation. We propose a concept by which the gut microbiota fuels metabolic inflammation and dysregulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available