Journal
BIOPHYSICAL JOURNAL
Volume 95, Issue 6, Pages 2806-2821Publisher
CELL PRESS
DOI: 10.1529/biophysj.108.132563
Keywords
-
Categories
Funding
- National Institutes of Health [P41-RR05969, R01-GM067887]
- Pittsburgh Supercomputing Center and the National Center for Supercomputing Applications via Large Resources Allocation Committee [MCA93S028]
- Turing Xserve Cluster
- Edelheit fellowship
Ask authors/readers for more resources
BAR domains are proteins that sense and sculpt curved membranes in cells, furnishing a relatively well-studied example of mechanisms employed in cellular morphogenesis. We report a computational study of membrane bending by BAR domains at four levels of resolution, described by 1), all-atom molecular dynamics; 2), residue-based coarse-graining (resolving single amino acids and lipid molecules); 3), shape-based coarse-graining (resolving overall protein and membrane shapes); and 4), a continuum elastic membrane model. Membrane sculpting performed by BAR domains collectively is observed in agreement with experiments. Different arrangements of BAR domains on the membrane surface are found to lead to distinct membrane curvatures and bending dynamics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available