Journal
BIOPHYSICAL JOURNAL
Volume 95, Issue 12, Pages 5489-5495Publisher
CELL PRESS
DOI: 10.1529/biophysj.108.131813
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Funding
- National Institutes of Health [GM58545]
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The stability of a compact RNA tertiary structure is exquisitely sensitive to the concentrations and types of ions that are present. This review discusses the progress that has been made in developing a quantitative understanding of the thermodynamic parameters and molecular detail that underlie this sensitivity, including the nature of the ion atmosphere, the occurrence of specific ion binding sites, and the importance of the ensemble of partially unfolded states from which folding to the native structure occurs.
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