Journal
BIOPHYSICAL JOURNAL
Volume 94, Issue 8, Pages 3159-3166Publisher
CELL PRESS
DOI: 10.1529/biophysj.107.117150
Keywords
-
Categories
Funding
- NIDCD NIH HHS [N01-DC-6-0006] Funding Source: Medline
- PHS HHS [HHSN260-2006-00006-C] Funding Source: Medline
Ask authors/readers for more resources
We have pioneered what we believe is a novel method of stimulating cochlear neurons, using pulsed infrared radiation, based on the hypothesis that optical radiation can provide more spatially selective stimulation of the cochlea than electric current. Very little of the available optical parameter space has been used for optical stimulation of neurons. Here, we use a pulsed diode laser (1.94 mu m) to stimulate auditory neurons of the gerbil. Radiant exposures measured at CAP threshold are similar for pulse durations of 5, 10, 30, and 100 mu s, but greater for 300-mu s-long pulses. There is evidence that water absorption of optical radiation is a significant factor in optical stimulation. Heat-transfer-based analysis of the data indicates that potential structures involved in optical stimulation of cochlear neurons have a dimension on the order of similar to 10 mu m. The implications of these data could direct further research and design of an optical cochlear implant.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available