Journal
TOXICOLOGY REPORTS
Volume 7, Issue -, Pages 559-570Publisher
ELSEVIER
DOI: 10.1016/j.toxrep.2020.03.010
Keywords
Epigenetics; microRNA; miRNA; Toxicology; Zebrafish
Categories
Funding
- National Institutes of Health, National Institute of Environmental Health Sciences [R03 ES030545]
- Purdue University
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Zebrafish (Danio rerio) are an integrative vertebrate model ideal for toxicity studies. The zebrafish genome is sequenced with detailed characterization of all life stages. With their genetic similarity to humans, zebrafish models are established to study biological processes including development and disease mechanisms for translation to human health. The zebrafish genome, similar to other eukaryotic organisms, contains microRNAs (miRNAs) which function along with other epigenetic mechanisms to regulate gene expression. Studies have now established that exposure to toxins and xenobiotics can change miRNA expression profiles resulting in various physiological and behavioral alterations. In this review, we cover the intersection of miRNA alterations from toxin or xenobiotic exposure with a focus on studies using the zebrafish model system to identify miRNA mechanisms regulating toxicity. Studies to date have addressed exposures to toxins, particulate matter and nanoparticles, various environmental contaminants including pesticides, ethanol, and pharmaceuticals. Current limitations of the completed studies and future directions for this research area are discussed.
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