Journal
FUTURE MICROBIOLOGY
Volume 16, Issue 10, Pages 721-729Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2020-0232
Keywords
cross-protection; Streptococcus suis; subunit vaccine
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Aim: This study aims to develop a subunit vaccine with high cross-protection for Streptococcus suis. Materials & methods: Four-week-old female BALB/c mice were first immunized with a single and mixed protein. Various indicators, such as antibody titers and various cytokine levels, were further analyzed. Results: The results showed that purified recombinant proteins IF-2 and 1022 had a good protective effect against lethal doses of S. suis serotype 2 and S. suis serotype 9. This study showed immunization with recombinant proteins. Conclusion: IF-2 and 1022 can enhance cross-protection against S. suis serotypes 2 and 9.
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