Journal
CELL CHEMICAL BIOLOGY
Volume 27, Issue 4, Pages 365-375Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2020.03.013
Keywords
-
Categories
Funding
- National Cancer Institute [R01CA204232, R01CA166413]
- National Institute of Neurological Disorders and Stroke [1R61NS109407]
Ask authors/readers for more resources
Ferroptosis is a recently described form of cell death driven by iron-dependent lipid peroxidation. This type of cell death was first observed in response to treatment of tumor cells with a small-molecule chemical probe named erastin. Most subsequent advances in understanding the mechanisms governing ferroptosis involved the use of genetic screens and small-molecule probes. We describe herein the utility and limitations of chemical probes that have been used to analyze and perturb ferroptosis, as well as mechanistic studies of ferroptosis that benefit Led from the use of these probes and genetic screens. We also suggest probes for ferroptosis and highlight mechanistic questions surrounding this form of cell death that will be a high priority for exploration in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available