Journal
BIOPHYSICAL CHEMISTRY
Volume 186, Issue -, Pages 22-30Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bpc.2013.10.002
Keywords
Conformational selection; Induced fit; Allostery; Allosteric; Binding; Molecular recognition
Funding
- National Cancer Institute
- National Institutes of Health [HHSN261200800001E]
- Intramural Research Program of the NIH
- Center for Cancer Research
Ask authors/readers for more resources
The fact that we observe a single conformational selection event during binding does not necessarily mean that only a single conformational selection event takes place, even though this is the common assumption. Here we suggest that conformational selection takes place not once in a given binding/allosteric event, but at every step along the allosteric pathway. This view generalizes conformational selection and makes it applicable also to other allosteric events, such as post-translational modifications (PTMs) and photon absorption. Similar to binding, at each step along a propagation pathway, conformational selection is coupled with induced fit which optimizes the interactions. Thus, as in binding, the allosteric effects induced by PTMs and light relate not only to population shift; but to conformational selection as well. Conformational selection and population shift take place conjointly. (c) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available