Journal
ACTA CHIMICA SLOVENICA
Volume 67, Issue 4, Pages 1044-1052Publisher
SLOVENSKO KEMIJSKO DRUSTVO
DOI: 10.17344/acsi.2019.5492
Keywords
Heterogeneous catalyst; Cu/C nanoparticle; Tetrazoles; One-pot three component reaction; [3+2] Cycloaddition reaction
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Funding
- Shiraz University of Technology
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A new, efficient and convenient method for the synthesis of 5-substituted 1H-tetrazole derivatives with a wide range of substituents in good to excellent yields has been developed. The synthesis was performed by the one-pot three-component [3+2] cycloaddition reaction between aldehyde, hydroxylamine and sodium azide in the presence of Cu/C. The reaction probably proceeds by the in situ formation of nitriles followed by successive [3+2] cycloaddition with sodium azide. A variety of aldehydes were used to obtain the corresponding tetrazoles. The catalyst was recovered by simple filtration and reused at least five times without significant loss of catalytic activity. The use of this method offers additional advantages for the synthesis of 5-substituted 1H-tetrazole derivatives, including the easy availability of starting materials, mild conditions, experimental simplicity and good yields.
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