Related references
Note: Only part of the references are listed.Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
Scott R. Daigle et al.
BLOOD (2013)
A Medicinal Chemistry Perspective for Targeting Histone H3 Lysine-79 Methyltransferase DOT1 L
Justin L. Anglin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L
Lisheng Deng et al.
MEDCHEMCOMM (2013)
Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L
Aravind Basavapathruni et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2012)
Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design
Li Di et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
Scott R. Daigle et al.
CANCER CELL (2011)
PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 3: Comparative Assessement of Prediction Methods of Human Clearance
Barbara J. Ring et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes
Debabrata Biswas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Epigenetic modifications and human disease
Anna Portela et al.
NATURE BIOTECHNOLOGY (2010)
11q23/MLL Acute Leukemia : Update of Clinical Aspects
Hayato Tamai et al.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY (2010)
The Operational Multiple Dosing Half-life: A Key to Defining Drug Accumulation in Patients and to Designing Extended Release Dosage Forms
Selma Sahin et al.
PHARMACEUTICAL RESEARCH (2008)
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data:: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver
Zoe E. Barter et al.
CURRENT DRUG METABOLISM (2007)
Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein
PM Ayton et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
T Nakamura et al.
MOLECULAR CELL (2002)
MLL targets SET domain methyltransferase activity to Hox gene promoters
TA Milne et al.
MOLECULAR CELL (2002)
Share Paper
